+ General Considerations

  • Dermal melanoma is rare in cats but 50% are malignant
  • Etiology is unknown but alterations in oncogenes, tumor suppressor genes, and immune surveillance are involved
  • Feline melanoma can be induced experimentally with FeSV but unlikely to be involved naturally
  • Mean age 10-12 years
  • Sites: head and especially ocular and eyelids


+ Surgery

  • ± gene therapy, radiation therapy, local hyperthermia, photodynamic therapy, and intralesional cisplatin
  • Durable response to course-fraction radiation therapy
  • Responses are short-lived for photodynamic therapy, hyperthermia, and intralesional cisplatin
  • Chemotherapy is usually ineffective (agents include mitoxantrone, doxorubicin, platinums, and melphalan)