+ Lymphangioma
- It is a benign tumor arising from lymphatic endothelial cells
- Arises as either a congenital malformation (i.e., hamartoma) or following failure of primitive lymphatic sacs to achieve venous communication
- Often presents as a large, spongy, and poorly circumscribed mass which may be associated with lymph oozing from the surface or single to multiple fistulae
- Treatment: surgical resection with wide margins (as local tumor recurrence is common due to infiltrative growth and poor margins), marsupialization, and radiation therapy
+ Lymphangiosarcoma
- It is a very rare tumor arising from lymphatic endothelial cells
- Composed of lymphatic vessels forming capillary, cavernous, or cystic spaces
- Associated with or sequelae to chronic lymphatic obstruction
- Sites: subcutaneous ± liver, pericardium and nasopharynx have been reported
- Gross appearance: soft, cyst-like, and edematous ± invasive
- Clinical signs are usually associated with extensive edema and drainage of lymph through the skin or mass
- Moderate to high metastatic potential
- Differentiated from lymphangioma by pleomorphism, mitotic activity, and lack of dermal collagen support
+ Prognosis
Unknown but aggressive surgical treatment recommended and possibly responsive to radiation therapy