+ Lymphangioma

  • It is a benign tumor arising from lymphatic endothelial cells
  • Arises as either a congenital malformation (i.e., hamartoma) or following failure of primitive lymphatic sacs to achieve venous communication
  • Often presents as a large, spongy, and poorly circumscribed mass which may be associated with lymph oozing from the surface or single to multiple fistulae
  • Treatment: surgical resection with wide margins (as local tumor recurrence is common due to infiltrative growth and poor margins), marsupialization, and radiation therapy

+ Lymphangiosarcoma

  • It is a very rare tumor arising from lymphatic endothelial cells
  • Composed of lymphatic vessels forming capillary, cavernous, or cystic spaces
  • Associated with or sequelae to chronic lymphatic obstruction
  • Sites: subcutaneous ± liver, pericardium and nasopharynx have been reported
  • Gross appearance: soft, cyst-like, and edematous ± invasive
  • Clinical signs are usually associated with extensive edema and drainage of lymph through the skin or mass
  • Moderate to high metastatic potential
  • Differentiated from lymphangioma by pleomorphism, mitotic activity, and lack of dermal collagen support

+ Prognosis

Unknown but aggressive surgical treatment recommended and possibly responsive to radiation therapy