+ General Considerations

  • Infiltrative lipomas are locally aggressive with infiltration of normal muscle and fibrous tissue
  • Large breed dogs are predisposed with a median body weight 30.5 kg
  • Sex predisposition: females with a male-to-female ratio of 1:4
  • Well-differentiated adipocytes without evidence of anaplasia and considered benign
  • Infiltrative lipomas invade muscle, fascia, nerve, myocardium, joint capsule, and bone
  • Infiltrative lipomas can cause pressure atrophy of muscles, pain, and interfere with normal movement
  • Aggressive treatment may be required for local control as recurrence is common
  • Radiation therapy can be considered for unresectable tumors as decreased blood supply may diminish growth
  • Prognosis: 36% local tumor recurrence, median DFI 239 days, and 1-year DFI 67%