+ General Considerations
- Infiltrative lipomas are locally aggressive with infiltration of normal muscle and fibrous tissue
- Large breed dogs are predisposed with a median body weight 30.5 kg
- Sex predisposition: females with a male-to-female ratio of 1:4
- Well-differentiated adipocytes without evidence of anaplasia and considered benign
- Infiltrative lipomas invade muscle, fascia, nerve, myocardium, joint capsule, and bone
- Infiltrative lipomas can cause pressure atrophy of muscles, pain, and interfere with normal movement
- Aggressive treatment may be required for local control as recurrence is common
- Radiation therapy can be considered for unresectable tumors as decreased blood supply may diminish growth
- Prognosis: 36% local tumor recurrence, median DFI 239 days, and 1-year DFI 67%