Veterinary Society of
Surgical Oncology

General Considerations

  • uncommon malignant tumor of adipose tissue
  • no breed or sex predilection
  • liposarcoma does not arise from malignant transformation of lipoma
  • liposarcoma associated with type-C virus particles in cats (i.e., retroviral infection) and reported secondary to glass foreign body in a dog
  • biologic behaviour: aggressive and locally invasive ± metastasis to lungs, liver, and bone
  • sites: subcutaneous tissue (axial or appendicular), visceral (spleen and liver), and skeletal
  • liposarcomas can infiltrate into veins, lymphatics, and underlying muscle
  • prognosis: guarded to good
  • 28% (12/43) local tumor recurrence with 83% (10/12) of these occurring in dogs with marginal excision
  • metastatic rate < 10%
  • MST 694 days
  • surgical dose is the only prognostic factor for survival with MST for incisional biopsy 183 days, 649 days for marginal excision, and 1,188 days for wide excision
  • however, MST for tumor size < 4 cm is 961 days and ≥ 4 cm is 612 days
  • metastatic predictors in humans: histologic grade and tumor size

See Soft Tissue Sarcoma for more information

LIPOSARCOMA

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