Veterinary Society of
Surgical Oncology

PATHOPHYSIOLOGY

General Considerations

  • uterine tumors are rare and account for 0.2%-1.5% of all feline tumors
  • uterine ADC is more common in cats and arises from the endometrium (= endometrial carcinoma)
  • metastatic sites include cerebrum, eye, ovary, adrenal glands, lungs, liver, kidney, bladder, colon, diaphragm, and regional lymph nodes
  • other uterine tumors include leiomyoma, leiomyosarcoma, FSA, LSA, fibroma, and lipoma

CLINICAL FEATURES

Clinical Features

  • middle-aged to older animals
  • abdominal enlargement with palpable abdominal mass
  • vaginal discharge is common and can vary from purulent to mucoid to darkly hemorrhagic
  • other signs include abnormal estrous cycles, polyuria-polydipsia, vomiting, and abdominal distension

Diagnosis

  • abdominal palpation
  • survey radiographs and ultrasonography to confirm origin of mass
  • histopathology

Treatment

  • ovariohysterectomy
  • role and effectiveness of chemotherapy and radiation therapy is unknown

Prognosis

  • surgical excision is curative for leiomyoma and other benign lesions
  • prognosis is good for leiomyosarcoma and other malignant tumors if surgical excision is complete and there is no evidence of metastatic disease
  • prognosis is guarded for feline endometrial carcinoma due to metastatic potential
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