Veterinary Society of
Surgical Oncology

General Considerations

  • odontogenic tumors arise from dental lamina and may arise from either dental epithelium or nests of epithelial cells
  • odontogenic tumors account for 2.4% of feline oral tumors with all cats < 18 months
  • odontogenic tumors are benign and do not metastasize
  • classification of epithelial odontogenic tumors: inductive and non-inductive
  • classification is based on ability of tumor to induce a stromal reaction in adjacent connective tissue

Inductive Epithelial Odontogenic Tumors

General Considerations

  • types: ameloblastic fibroma, dentinoma, and ameloblastic complex and compound odontoma

Inductive Fibroameloblastoma

  • rare
  • signalment: young (6-18 months) and male
  • location: rostral to and including canine tooth of either the mandible or maxilla (common)
  • benign but causes variable degree of bone destruction, production, and expansion
  • teeth deformity is common
  • treatment: mandibulectomy or maxillectomy, surgical debulking, cryosurgery, or radiation therapy
  • good control rates with aggressive therapy
  • adjunctive radiation therapy has been used with good results in 3 cats with incompletely excised tumors
  • metastasis has not reported

Odontoma

  • odontomas are rare and benign tumors arising from dental follicle during the early stages of tooth development
  • odontoma is diagnosed when there is evidence of induction of both enamel and dentin
  • odontoma is intraosseous and locally invasive but does not metastasize
  • treatment: surgical debulking and cryosurgery or wide surgical excision

Non-Inductive Epithelial Odontogenic Tumors

General Considerations

  • types: ameloblastoma and calcifying epithelial odontogenic tumor

Ameloblastoma

  • ameloblastoma is often confused with acanthomatous epulis due to similar histologic characteristics
  • ameloblastoma is intraosseous and locally invasive but does not metastasize
  • treatment: mandibulectomy or maxillectomy, surgical debulking, cryosurgery, or radiation therapy
  • 2-year mean survival time following radiation therapy in dogs

Calcifying Epithelial Odontogenic Tumor

  • calcifying epithelial odontogenic tumor is a benign and rare tumor of the tooth-forming apparatus
  • calcifying epithelial odontogenic tumors produce a mineralized substance and amyloid
  • biologic behaviour: slow invasion of adjacent tissue resulting in osteolysis or deformation of mandible or maxilla
  • treatment: mandibulectomy or maxillectomy

ORAL ODONTOGENIC TUMORS

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